Can internal dosimetry estimates for different age groups be developed and used in quantitative risk assessment?
To place the analytical results in perspective, the risk characterization will usually try to describe the degree of uncertainty and variability in the analysis. The following questions may be particularly pertinent to such a discussion. Are children more variable in their pharmacokinetic responses than adults? How do we assess and apply this information? The role of variability in the risk assessment process can range from purely qualitatitive (e.g., people are different from one another, so we are not as certain as we would like to be about the degree of risk) to semiquantitative (e.g., people vary considerably in metabolizing chemical X, so it seems prudent to use a half-log toxicokinetic uncertainty factor) to fully quantitative (e.g., we have sufficient individual data to plot the population distribution of effective internal doses per unit of external dose, so let us show the risk manager the cleanup options that protect the 50th, 75th, 90th, and 95th percentiles). The fully quan
To place the analytical results in perspective, the risk characterization will usually try to describe the degree of uncertainty and variability in the analysis. The following questions may be particularly pertinent to such a discussion. Are children more variable in their pharmacokinetic responses than adults? How do we assess and apply this information? The role of variability in the risk assessment process can range from purely qualitatitive (e.g., people are different from one another, so we are not as certain as we would like to be about the degree of risk) to semiquantitative (e.g., people vary considerably in metabolizing chemical X, so it seems prudent to use a half-log toxicokinetic uncertainty factor) to fully quantitative (e.g., we have sufficient individual data to plot the population distribution of effective internal doses per unit of external dose, so let us show the risk manager the cleanup options that protect the 50th, 75th, 90th, and 95th percentiles). The fully quan
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