Can ING proteins selectively induce apoptosis in prostate cancer cells?
Principle Investigator: Karl Riobowol, University of Calgary – Calgary Relevance: Dr. Riobowol’s team has discovered a group of proteins called ING proteins, which keep healthy cells growing normally, and cause damaged cells to die. When these proteins are inactivated, the cells can become cancerous. ING proteins have not been well studied in prostate cancer, so the team now plans to determine whether the activity of ING proteins is altered in prostate cancer cells. Once these proteins are more fully understood, they may be useful in the development of new treatments for prostate cancer. Description: Dr. Riobowol’s group has learned that levels of some ING proteins vary widely in prostate cancer cells, and that these cells vary in their susceptibility to ING-induced cell death. They now plan to use laboratory-grown prostate cancer cells to discover which genes are affected by ING proteins and whether these genes are related to the cancer cell’s likelihood of dying in response to ING pr
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