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Can I use GSEA with gene sets that have both up- and down-regulated genes?

April 26, 2017down-regulated gene genes gsea

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Can I use GSEA with gene sets that have both up- and down-regulated genes?

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The GSEA software does not yet support this, but you can use the enrichment statistic with gene sets that include both up- and down-regulated genes. For one approach, see Lamb, et. al. (2006).