Can I use Glen Twist Columns on the Beckman Oligo 1000 synthesizer?
RESPONSE:Glen Twist columns have a higher resistance to flow than the synthesis columns sold by Beckman. This reduced flow rate makes synthesis at scales less than 0.2 micromole inefficient which results in poor quality syntheses. Syntheses at scales of 0.2 and 1.0 micromole can be done using Twist columns, however, you need to disable two automatic halt signals. To do this go to Other Functions in the main menue. Select successive menu options outlined below and turn off the detectors for Empty Reagent and Missing Column.
