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Can I use GastroPlus to predict the PK response from in vitro or pre-clinical data?

April 26, 2017Data gastroplus pk pre-clinical predict Response Vitro

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Can I use GastroPlus to predict the PK response from in vitro or pre-clinical data?

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Of course! The Metabolism and Transporter module in GastroPlus includes a convenient units converter for IVIVE (in vitro – in vivo extrapolation). The animal gut and PBPK physiologies provided in GastroPlus allow you to run simulations for pre-clinical species, figure out the mechanism of the drug’s interactions in the body, and properly scale to human based on known differences between physiologies.