Can I use a grenade or other template weapon to target a spot on the ground or barricade next to a hidden model?
You must always target a fighter unless the weapon or scenario allows otherwise. Just because you have a frag grenade and you want to target a hidden model you have no line-of-sight (LOS). Without LOS you cannot elect to throw the grenade at the barricade in front of the hidden model unless otherwise specified (see gas grenades in the armoury section of the Necromunda ORB). This prevents you from targeting the bulkhead (+1 for a large target) instead of the Juve behind heavy cover that just sprinted 12″ (-3 total). The bottom line is that unless the weapon description or scenario allows it you must always target a fighter or objective.