Can I take aspirin, 325 mg,, and Advil PM?
No! ASPIRIN may interact with IBUPROFEN (in Advil, Advil PM caplets) Ibuprofen may interfere with the heart protective effects of low-dose aspirin. Your doctor may consider using a pain relieving agent that does not interfere with these protective effects. Ibuprofen is broken down by the liver and removed from the body in the urine. If this happens too quickly, then potentially less ibuprofen would be available for the body to use and blood levels could become too low. This could make ibuprofen less effective. Aspirin may cause ibuprofen to be broken down at a faster rate than normal. Based on information from a number of studies, this does not appear to have a significant impact on the therapeutic effect of ibuprofen. However, both of these drugs can cause stomach irritation and may potentially damage the lining of the stomach. The risk of experiencing these side effects may be increased when aspirin and ibuprofen are taken at the same time. You may want to ask your healthcare provide
