Can I run multiple instances of Sylpheed?
Yes, Sylpheed 3.1 adds support for this often requested feature. The format of the multiple instances command is as follows: sylpheed –instance-id ID –configdir path-to-alternative-configdir Default ID is set to sylpheed, so you can specify any other instance ID. The ID is used for the name of unix domain socket (under UNIX), or mutex name (under Windows). configdir specifies the configuration directory, i.e. the location of configuration files you want to use with the given instance.