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Can I knockdown highly stable proteins using shRNAs?

April 26, 2017highly knockdown Proteins shrnas STABLE

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Can I knockdown highly stable proteins using shRNAs?

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10 Posted

Since the library is lentiviral based, it is ideal for knocking down both transcripts and proteins that are very stable. Stable integration of the shRNA into the host chromosome, allows for long-term silencing, thus allowing for longer turnover and degradation half-lives.