Can I install new Schrödinger software in an existing Schrödinger directory?
We recommend that you install software for a new release in a new SCHRODINGER directory. If you are testing beta versions of the software, you should always install the beta software in a separate SCHRODINGER. If you are installing an upgrade, with the same major version numbers, you can install into the same SCHRODINGER as the release to which it is an upgrade. If you are evaluating a new product, you can check the compatibility with existing products by comparing the first two digits of the 5-digit Maestro version on the CD or in the download with those in the installation.