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Can I hybridize samples to an array from a species other than the organism for which the array was designed? For example, can I hybridize a mouse sample to a rat chip?

April 26, 2017array designed hybridize mouse organism Rat sample samples species

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Can I hybridize samples to an array from a species other than the organism for which the array was designed? For example, can I hybridize a mouse sample to a rat chip?

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Although there may exist a high degree of homology between closely related species, sufficient sequence differences may exist which could interfere with hybridization and data interpretation. Although some researchers have explored his approach, it is not recommended by our facility.