Can hepatitis C glomerulonephritis present as FGS?
” Hepatitis C glomerulonephritis (HepC-GN) is an immune complex GN that often has a cryoglobulinemic or type I membranoproliferative GN phenotype (Kidney Int 46:1255-1263, 1994), but also can manifest other expressions of immune complex injury, e.g. membranous GN, focal or diffuse proliferative GN, or acute diffuse proliferative GN that resembles acute post-infectious GN (Lab Invest 70:157A, 1994). The sclerotic phase of a chronic focal immune complex GN may suggest FSGS by light microscopy, but IF and EM evaluation should reveal this. In an analysis of the prevalence of hepatitis C seropositivity in patients with various glomerular diseases that has been published only in abstract form (Lab Invest 70:157A,1994), 0/7 patients with the collapsing variant of FSGS were positive, and only 1/28 patients with typical FSGS was positive. My suspicion is that in this patient and in the patient under consideration, the hepatitis C infection is not the cause of the FSGS. c) “Is hepatitis C glomer
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- Can hepatitis C glomerulonephritis present as FGS?
