Can DVT lead to amputation?
A. Most cases of amputation associated with blood clots involve clots of the arteries. Such clots prevent the flow of blood to tissues beyond the blockage, causing tissue death (necrosis). Rare instances of amputation associated with deep vein thrombosis occur in individuals with “blue leg” (phlegmasia cerulea dolens), in which there is a massive venous thrombosis of the upper leg as well as an advanced malignancy (cancer) elsewhere in the body.