Can coadministration of oxycodone and morphine produce analgesic synergy in humans?
Author(s): Grach M, Massalha W, Pud D, Adler R, Eisenberg E Affiliation(s): Department of Anaesthesiology, Carmel Hospital, Haifa, Israel. Publication date & source: 2004-09, Br J Clin Pharmacol., 58(3):235-42. Publication type: Clinical Trial; Randomized Controlled Trial AIMS: The coadministration of subantinociceptive doses of oxycodone with morphine has recently been shown to result in a synergistic antinociceptive effect in rats. The present study was aimed to investigate the possibility that coadministration of morphine and oxycodone can produce a similar synergistic effect in humans exposed to an experimental model of cold pressor test (CPT). METHODS: The enriched enrollment design was used to exclude ‘stoic’ and ‘placebo responders’ in a single-blind fashion. ‘Nonstoic’, placebo ‘nonresponder’ female volunteers (n = 30) were randomly assigned to receive 0.5 mg kg(-1) oral morphine sulphate, 0.5 mg kg(-1) oral oxycodone hydrochloride, and the combination of 0.25 mg kg(-1) morphin
