Can cancer develop after Macrolane injection?
The amount of hyaluronic acid injected thorugh the Macrolane VRF treatment is extremely small (2 % of the implanted volume) compared with the natural concentration of hyaluronic acid in the skin. Besides, the hyaluronic acid molecules present in the NASHA gels are bound to each other and confined to the gel network and therefore not available to exert any biological activity. In order to participate in any biological process, including cancer, the hyaluronic acid molecules would have to leave the gel network in substantial amounts. The degradation process of the NASHA gels is very slow ( several months) compared to the degradation rate of natural hyaluronic acid polymers present in the skin (half-life: 16 h in the dermis) or in the circulation (half-life:3 – 4 minutes). Therefore, the very small amount of free hyaluronic acid leaving the gel network every day due to the gel degradation process, would be diluted by several orders of magnitude by the amount of hyaluronic acid naturally p
