Can anyone tell me about natural thrombolytic drugs?
Thrombolytic drugs are used in medicine to dissolve blood clots in a procedure termed thrombolysis. They limit the damage caused by the blockage of the blood vessel. Uses Thrombolysis is used in for myocardial infarction (heart attack), ischemic strokes, deep vein thrombosis and pulmonary embolism to clear a blocked artery and avoid permanent damage to the perfused tissue (e.g. myocardium, brain, leg) and death. A less frequent use is to clear blocked catheters that are used in long-term medical therapy. It should be noted that thrombolytic therapy in hemorrhagic strokes is contraindicated, as its use in that situation would prolong bleeding into the intracranial space and cause further damage. The thrombolytic drugs include: t-PA (alteplase Activase) reteplase (Retavase) tenecteplase (TNKase) anistreplase (Eminase) streptokinase (Kabikinase, Streptase) urokinase (Abbokinase) These drugs are most effective if administered immediately after it has been determined they are clinically app
Thrombolytic, or clot-buster, drugs were first discovered in the 1950s, and in the 1980s, after a long phase of experimentation, The clot-buster drugs such as tissue plasminogen activator (tPA) Urokinase (UK) and Streptokinase (SK) have revolutionized the treatment of myocardial infarction in recent years. tPA and UK are produced by human organs in very less quantity SK is normally produced by a bacterium (Streptococcus), it can be produced by fermentation Streptokinase is a protein produced by Streptococcus species, and is the most widely used thrombolytic agent today. The effects of natural streptokinase on the treatment outcome with patients suffering from MI has been similar to other prominent thrombolytic agents and it remains the agent of choice in India as it is much cheaper. A recombinant-DNA based process for the high level production of streptokinase from E. coli was indigenously developed by the Institute of Microbial Technology, Chandigarh,. The drug is expected to be launc
