Can anyone explain why Vitamin A deficiency can lead to renal stone formation?
Found this It may be concluded that there is a connection between vitamin A deficiency and the formation of phosphate calculi; at least, that in rats vitamin A deficiency may be a cause of phosphate calculi in the urinary tracts. It is known that absence of the fat-soluble vitamin from the food causes typical changes in the epithelial cells of the mucous membranes, namely keratinization, as shown by the xerophthalmia. Probably such a morbid change of the epithelial cells of the tubules, in the last instance, gives the impulse to the deposition of calcium casts, which, once liberated, by means of further deposition of salts from the urine, grow to greater concrements.
