Can antioxidant therapy prevent oxidative stress?
There is also evidence that antioxidant therapy can protect against the development of several degenerative diseases, such as atherosclerosis, cancer, by reducing oxidative stress. However, there is no evidence that antioxidants can prolong maximum life span in rodents or humans. In general, the nature and the source of the reactive radical species that may contribute to oxidative stress and protein oxidation is only partially understood, because most of the methods currently used to investigate oxidative reactions are non-specific, and the reactive radical intermediates are short-lived and difficult to detect directly. Better understanding the antioxidant mechanisms in vivo may help to find combinations of antioxidants to prolong life. Mitochondria and apoptosis research: Mitochondiral oxidative stress with aging may be liked to apoptosis. Apoptosis is a highly regulated form of cell death characterized by specific morphological, biochemical, and molecular events. However, its role du