Can antiemetics really relieve pain?
Author(s): Derbent A, Uyar M, Demirag K, Uyer M, Kurtoglu E, Goktay A Affiliation(s): Department of Anesthesiology and Reanimation, University Hospital, Izmir, Turkey. Publication date & source: 2005-07, Adv Ther., 22(4):307-12. Publication type: The analgesic properties of 2 antiemetic agents-metoclopramide and ondansetron-were investigated in studies which showed that metoclopramide may decrease postoperative opioid requirements, but the analgesic effect of ondansetron is controversial. The postoperative effects of metoclopramide and ondansetron on pain in patients undergoing laminectomy were evaluated. Forty six patients were randomized into 3 groups: group M, which consisted of 15 patients who received intravenous (IV) metoclopramide 0.5 mg 30 minutes before surgery; group O, which consisted of 16 patients who received ondansetron IV 0.1 mg 30 minutes before surgery; and group C, which consisted of 15 patients who received the same volume of saline IV 30 minutes before surgery. The
