Can anorexia or just being underweight cause POF?
No data exist to indicate that anorexia can cause POF. Low estrogen production, be it because of an ovarian cause (as in POF) or a central cause (due to inadequate FSH secretion because of hypothalamic amenorrhea, as may occur in anorexia), can produce similar symptoms. Ovarian failure is documented by determining that FSH levels, produced by the anterior pituitary gland, are markedly elevated.
