Can an individual naturally have an unequal proportion of X- and Y-bearing sperm cells even if there is a family history of mostly female or male offspring?
There is no information of which we are aware that would indicate some men naturally produce an unbalanced number of X- and Y-bearing sperm cells. This seems true even when there is a family history of mostly female or male offspring. If you have significant doubt about your situation, it is possible to have a specimen tested by FISH prior to using the MicroSort procedure.
