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Can Amoxicillin and Augmentin be given only once a day for prophylaxis?

April 26, 2017Amoxicillin Augmentin given PROPHYLAXIS

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Can Amoxicillin and Augmentin be given only once a day for prophylaxis?

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Apparently not. Amoxicillin and Augmentin both have extremely short half-lives (1-1.5 hours). This means that most of Amoxicillin/Augmentin is removed from the body in ~10hours. If a dose is skipped, the child is actually unprotected for 1-2 days. Azithromycin has a longer half-life (~1.5 days), can be taken once per day and is easier on the GI tract, but there are reports of macrolide resistant strains of GABHS.