Can a hormonal problem cause recurrent miscarriage?
It is tempting to assume that administration of the pregnancy hormones HCG and progesterone would increase the chance of a successful outcome but there is no definite evidence to demonstrate that these treatments are effective. Some women have heard anecdotal stories of hormones being successful. Most IVF centres advocate hormone supplements in pregnancy and there is no evidence of any adverse effects. Gestone (progesterone) 100 mg injections, HCG 5000 units by injection, Crinone (progesterone) 4 or 8% on alternate days and Cyclogest pessaries 400mg each night until about 14 weeks are typical regimens. PCOS (Q7.2) and high levels of LH are thought to be associated with miscarriage. It may be that metformin will prove to be effective, if there is evidence of such problems, but it will be some while before we have evidence.
