Can a diagnosis of PD be made based solely on the presence of two or more cardinal features?
Because there are no biological markers for PD, a thorough, accurate history and physical examination are key to the diagnosis. A diagnosis of PD used solely on the presence of two or more of the cardinal features may be misleading. • What are some features that differentiate Parkinson-like syndromes from PD? Features that differentiate Parkinson-like syndromes from PD include: lack of a clinical response to levodopa or a dopamine agonist; lack of asymmetric motor signs; rapid decline over several months to one year; and presence of clinically significant dementia early in the course of predating motor signs. • What disease characteristics may be used to distinguish PD, drug-induced Parkinsonism, and other Parkinson-like syndromes? Disease characteristics that may be used to distinguish between Parkinson’s disease, drug-induced parkinsonism, and other Parkinson-like syndromes include: asymmetric vs. symmetric motor signs; time frame of progression; and response to pharmacologic therapy
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