Can 5-HTP be taken with St. John’s wort extract?
Yes. In fact, the two seem to work very well together. St. John’s wort extract has been shown in over 25 double-blind studies to be as or more effective than antidepressant drugs in the treatment of mild to moderate depression. In more severe cases, I recommend using 5-HTP along with St. John’s wort. Be sure to use the St. John’s wort extract standardized for 0.3% hypericin. The dosage for this extract is typically 300 mg three times per day. When using it in combination with 5-HTP I recommend 50-100 mg of 5-HTP and 150-300 mg of St. John’s wort extract three times daily.
