been used to understand scleroderma?
As in other areas of medicine and biology, we have leant a lot from other species. In particular there is a naturally occurring mouse that develops a condition similar to scleroderma. This mouse has been studied and has given important clues about the way in which a protein called fibrillin, that regulates the elasticity of skin and blood vessels, might be altered in scleroderma. back to top Q: I am having a lot of trouble with my feet. They are very tight and inflamed and burn a lot, with the result they are very painful. A: Foot pain can arise in several ways in scleroderma. Early in the disease there can be arthritic pain from joint inflammation. Later Raynaud’s attacks can be painful especially if they lead to ulcers over the toes. Raynaud’s can also lead to burning discomfort when the feet warm up after an attack. However the commonest cause of foot pain is later in the disease, often after several years. There is shortening of the tendons and loss of soft tissue within the feet t
