Avoid starting Side Quests to facilitate Looting?
As it turns out many NPCs, additional Quest Givers, etc. are only spawned on demand, i.e. spawned when the appropriate side quest actually “requires” these characters. This means that quite a few buildings in the large cities (Chathalon, Qudinar, Ashos) are initially empty. Thus after you picked some door locks, and have paid off the alerted guards, you can enter these rooms and clean them out. Tip: Try to explore the cities first, avoiding to talk to Quest Givers, to make it easier to loot the chest-filled rooms that are as yet unpopulated.