Are triglyceride molecules present in the interstitial fluid metabolized to free fatty acids and glycerol?
According to the literature, it seems very reasonable to assume that triglycerides are immediately (4 hours) processed by lipoprotein lipase (LPL), an enzyme bound to adipocytes. In vitro studies have shown that triglycerides presented as emulsions and not in lipoprotein particles are readily hydrolyzed by LPL to glycerol and free fatty acids. Glycerol is a water-soluble molecule and requires no chaperone or carrier through interstitial fluids or the circulatory system. A short-term increase in glycerol concentration following LIPOCLASERXL treatment appears reasonable but has not been directly measured. However, interstitial levels of glycerol are similar to plasma levels. To date, no clinically significant elevation of plasma glycerol levels has been reported in any subject treated with the LIPOCLASERXL. One may extrapolate that interstitial glycerol levels were not significantly elevated in this compartment or sequestered subsequent to LIPOCLASERXL treatments. Free fatty acids are no
