Are there withdrawal effects if nefazodone is suddenly discontinued?
A withdrawal syndrome following the abrupt discontinuation of nefazodone has not been described. Because the half-lives of nefazodone and its active metabolites are 18 hours or less, it is prudent to taper nefazodone rather than abruptly discontinue it. • Is nefazodone toxic if an overdose is taken? Seven overdoses of nefazodone have been reported. The highest reported overdose was 11,200 mg. In some cases nefazodone was taken along with alcohol and/or other medications. All seven people who took an overdose recovered. • What precautions are necessary when switching between nefazodone and an MAO inhibitor? When switching from an MAO inhibitor to nefazodone, there should be a 14-day interval between the discontinuation of the MAOI and the initiation of nefazodone therapy. When switching from nefazodone to an MAOI, a 7-day interval is adequate, because of nefazodone’s short half-life. • What does nefazodone cost? Nefazodone is supplied in tablets ranging from 100 mg to 250 mg in strength
