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Are there specific guidelines for monitoring the QTc for persons who are taking QT-prolonging drugs?

April 26, 2017drugs guidelines monitoring persons qt-prolonging qtc taking

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Are there specific guidelines for monitoring the QTc for persons who are taking QT-prolonging drugs?

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• If possible, do not prescribe QT-prolonging drugs to anyone with a QT>440ms (female) or 420ms (male). • Do not allow QT to exceed 500ms during titration with these drugs • Beware of drug interactions that could result in greater exposure to the QT- prolonging drugs by blocking their metabolism or delaying clearance. Beware of drugs and or dietary supplements that also prolong the QT interval. Does female gender increase the sensitivity to QT-prolonging drugs and raise the risk of torsades de pointes with some drugs? Yes it does. Even at equivalent blood levels of the drugs, females have an increased sensitivity to drugs that prolong the QT interval and have a higher incidence of torsades de pointes. Look for comments regarding gender for specific drugs on our lists: Please click here to view the lists. PubMed searches on this topic area are available on our site. Is there an increased risk of developing torsades de pointes due to interactions between prescription drugs and OTC drugs