Are there special management guidelines or risks for pregnancy in PXE?
1, there does not appear to be a statistically significant risk of PXE causing an adverse outcome of pregnancy, or of pregnancy adversely affecting the subsequent course or severity of PXE. Because patients with PXE can have pregnancy related complications especially if they have underlying vascular disease or hypertension or are having ongoing eye problems, this can affect the management of the pregnancy. There is a slightly greater risk of GI bleeding, we think, but not as great as was previously thought. Eye monitoring by Amsler grid and periodic retinal examination are especially important during pregnancy, because the presence of neovascularization (growth of small vessels, which could then bleed and cause vision loss) might affect the method of delivery.
