Are there problems with generic lamotrigine?
Yes, most of the MedWatch adverse events involved a loss of response, but many involved a loss of response and additional side effects that did not occur with the brand-name Lamictal. According to a clinical nurse specialist who filed 37 MedWatch reports, she believes the generic equivalents of Lamictal differ markedly in bioequivalence, enough so that they may actually cause harm to patients. She also worries that the problems with generics AEDs are more pervasive than being reported.
