Are there other genetic conditions associated with an increased risk of pancreatic cancer?
There may be additional hereditary cancer syndromes that increase the risk of pancreatic cancer, and anyone concerned about their family history should talk with their doctor or genetic counselor. As research continues, doctors may learn more about the causes of inherited pancreatic cancer. Li-Fraumeni syndrome (LFS). People with LFS have up to a 50% chance of developing cancer by age 40 and a 90% chance of developing cancer by age 60. Some of the cancers most commonly associated with LFS are osteosarcoma (a type of bone cancer), soft tissue sarcoma, leukemia, breast cancer, brain cancer, and adrenal cortical tumors. An adrenal cortical tumor begins in the adrenal cortex, which is the outer layer of the adrenal glands. The adrenal glands are located on top of each kidney and are a part of the body’s endocrine (hormonal) system. Pancreatic cancer has occasionally been reported in such families, but the risk of developing pancreatic cancer is not known. LFS is a rare condition. The gene
