Are there other drugs that can be used to treat oseltamivir resistant H1N1 virus infection?
To date all the oseltamivir-resistant H1N1 isolates this season have been fully susceptible to the other available antiviral drugs, zanamivir and the adamantanes (amantadine and rimantadine). These would be alternative drugs for prevention or treatment of oseltamivir-resistant H1N1 infections. However, almost all influenza H3N2 viruses and, in some parts of the world, many H1N1 viruses are now resistant to the adamantane drugs. Consequently, effective use of these drugs would depend on knowledge of local patterns of circulating strains and their antiviral susceptibilities.
