Are there medications that should be avoided while taking Salvia divinorum?
Whether or not Salvia divinorum mixes well with other psychoactive drugs seems to be largely a question of “taste”. Some people have had terrifying, over-the-top experiences with such mixtures. Others have had wonderful, blissful experiences. Before mixing any psychoactive compounds, it is always a good idea that one first gets to know the effects of each compound on its own, and how he or she responds to various doses. In any case, a prudent individual interested in combining compounds would always start with lower-than-normal doses of each compound. Some compounds are synergistic–they work together to create a larger effect than would be expected (and hence smaller amounts should be taken). It is currently unknown if there are any risks associated with combining S. divinorum with other drugs.