Are there concerns about drug interactions?
Studies have been done with other anti-HIV drugs and rifampin, a common tuberculosis medicine. Drug interactions were minor and did not require adjusting the dose of any drug. Whether or not enfuvirtide interacts with other drugs, like methadone, psychiatric medicines or street drugs, is not known. People are encouraged to discuss the possible drug interactions between all of the therapies and substances they are taking with their doctor and/or pharmacist. Discussion Perhaps the most important thing to think about when considering a new drug is how it fits into the arsenal of current therapies. Enfuvirtide will likely never be considered as part of a first line regimen-for someone who has never used anti-HIV drugs. This is because it’s difficult to prepare and inject, and injection site reactions can be problematic. This drug may not even be very appropriate as part of a second line regimen-for someone who has used one regimen and is looking for other options due to drug failure or sid
