Are there any times when a 24-hour urine collection for creatinine clearance should be performed?
Measurement of creatinine clearance should be considered in circumstances when the estimating equation based on serum creatinine is suspected to be inaccurate (see question 34) or for patients with estimated GFR >60 mL/min/1.73 m2 when a more accurate clearance measure is required for clinical decision making. Such circumstance may occur in people who are undergoing evaluation for kidney donation, treatment with drugs with significant toxicity that are excreted by the kidneys (for example, high-dose methotrexate) or consideration for participation in research protocols. (See question 34 regarding discussion of other clearance measurements).
