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Are there any specific dissolution methods for ocular inserts?

April 26, 2017dissolution methods ocular

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Are there any specific dissolution methods for ocular inserts?

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A The only USP monograph for ocular systems that requires a dissolution test is the one for Pilocarpine Ocular System (see page 1560 fo USP 28). The dissolution test in this monograph does not use any of the compendial dissolution equipment. Instead, the systems are inserted in tubes and those are placed in a reciprocating shaker.We are not aware of any standard methods for this type of dosage forms.We recommend a search in the literature. The Web site www.NCBI.NLM.NIH.GOV may be useful.