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Are there any safety considerations for new refrigerants in chillers?

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Are there any safety considerations for new refrigerants in chillers?

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EPA believes that adherence to Standard 15 of the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE) will ensure the safety of technicians and building occupants. This standard applies to the use of all alternative refrigerants. In addition, systems designed and operated in accordance with ASHRAE Standard 3 will leak minimal amounts of refrigerant, thereby reducing ozone depletion and global warming impacts.

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