Are there any reports of heart attacks following use of mifepristone with drugs other than misoprostol?
In other countries, in the early 1990’s, three prostaglandins, misoprostol, sulprostone, and gemeprost, were used with mifepristone to terminate pregnancy. Heart attacks due to coronary spasm, one of them fatal, were reported in three of the more than 60,000 women given sulprostone (an injected prostaglandin) with mifepristone in other countries. As a result, sulprostone is no longer used in combination with mifepristone for medical abortion. Two cases of coronary spasm, one resulting in a heart attack, were reported for gemeprost when used in combination with mifepristone for medical abortion. Neither sulprostone nor gemeprost are approved for use in the U.S. 27. Is FDA considering withdrawing Mifeprex from the market? At this time, FDA believes that the benefits of Mifeprex outweigh the risks. As it does with all prescription drugs, FDA continues to monitor the safety and effectiveness of mifepristone.
