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Are there any real viral infections that can grotesquely alter human biological composition?

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Are there any real viral infections that can grotesquely alter human biological composition?

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not to point where its like zombie movies. but physical traits that exceed what we normally expect from the symptoms of viral infections (coughing, sneezing, flu-like, occasional swelling, organ failures etc). Maybe something like where a whole systematic melting of tissues occur, skin becomes easily pliable that adhering bandages will result in tearing the skin along with it when removing them… if not, what is the current most gruesome viral infections to date.

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