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Are there any more factors influencing successful crytotherapy applications ?

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Are there any more factors influencing successful crytotherapy applications ?

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Effective treatment for tissue destruction requires rapid freezing. Intracellular fluids will freeze forming spiked shards of ice which will rupture the cell membrane destroying the cell. Slow heat reduction causes a protective reaction of osmotic fluids flowing out of the cell leading to cell preservation instead of necrosis. Since tissue and formed layers of ice are poor thermal conductors, good results in cryotherapy can only be achieved with sufficient freezing power available to reach the distal end of the lesion. In all applications repeated freeze/thaw cycles will improve results dramatically. Freeze the lesion, let it thaw and freeze a second time in the same session. The CryoPen was designed for optimizing these factors.

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