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Are there any disadvantages of using artificial created organs to test chemicals as opposed to using animals?

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Are there any disadvantages of using artificial created organs to test chemicals as opposed to using animals?

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Another major disadvantage in creating/using artificial organs is that many of the functions of internal organs cannot be duplicated in a labaoratory. For example, the human liver carries out over 500 chemical reactions, many of which cannot be duplicated artificially.

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