Are there any advantages to testing microsomes prepared from treated hepatocytes, compared to in situ methods?
Microsomes prepared from treated hepatocytes can be used to determine CYP450 protein levels, providing additional insight into your compound’s effect on the liver. In addition, if you wish to probe additional enzyme pathways at a later date, microsome samples can be held from each donor, allowing additional enzymes to be tested at a future time.
Related Questions
- What are the advantages and disadvantages of testing using the three most common methods: urine, oral fluid, and hair?
- What information is available about the human donors from which the hepatocytes, microsomes, and S9 were prepared?
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