Are the putative gut chemoreceptor cells involved in food intake control?
A possible role for the cells expressing taste-signaling proteins, especially those expressing taste receptors, is the analysis of the chemical nature of the content of the GI in order to modulate appetite in response to the food ingested. Therefore, we looked at possible coexpression of taste signal transduction proteins with hormones and peptides that have been implicated in food intake control. Immunoreactivity for cholecystokinin (CCK), peptide YY (PYY), Ghrelin, orexin A, and glucagon-like peptide (GLP)1 was detected in the GI but did not colocalize with eGFP (Figure 5 for PYY, not shown for CCK, Ghrelin, orexin A, and GLP1).
