Are the memory and concentration impairments caused by Cushing’s reversible?
The brain does not function normally in any respect in a high-cortisol state. Research done by Monica Starkman, M.D. et al at the University of Michigan demonstrated actual decreased brain volume in certain areas of the brain associated with elevated cortisol levels, stress, or both. One area of the brain most affected is the hippocampus, an area critical in memory. Normalization of cortisol levels does produce some reversal of this low-volume state, and some who have had Cushing’s find significant improvement of their cognitive function when they are cured. Unfortunately, many continue to have some degree of difficulty with brain function, even a year or more after successful treatment. It is sometimes difficult to assess the level of loss and recovery in that there are age-related memory deficits which are normally-occurring, and depression due to having serious medical illness can also cause problems with memory and focus. A few helpful hints…. Not all internists, endocrinologists
