Are the liver function tests necessary during administration?
Yes: 0 No: 24 Abstain: 0 Discussion: Some members underlined that baseline liver function tests (LFT) should be required before administration of lovastatin 20 mg. Other committee members also felt that LFT should be required during therapy, for continued safe use of the drug. The committee members generally found that the risk of liver toxicity with statins seems to be similarly low and were not excessively concerned about patients with undiagnosed liver problems taking Mevacor Daily. 3. Statins have been associated with the development of serious muscle toxicity. Furthermore, drug-drug interactions with lovastatin may increase the risk of muscle toxicity. Is the risk of muscle toxicity with lovastatin 20 mg acceptable for an OTC drug; as applied to the population indicated in the label? Yes: 24 No: 0 Abstain: 0 Discussion: The subcommittee argued that the study indicated problems in the self-selection of patients for use of lovastatin, which may cause some safety concerns. 4. Lovasta
