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Are Random Antiretroviral Drug Levels Associated with Objectively Measured Adherence Behavior?

April 26, 2017adherence Antiretroviral associated Behavior drug levels measured Objectively

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Are Random Antiretroviral Drug Levels Associated with Objectively Measured Adherence Behavior?

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Liechty C, Alexander C, Harrigan R, Guzman D, Charlebois ED, Moss AR, Bangsberg DR; Conference on Retroviruses and Opportunistic Infections. Abstr 10th Conf Retrovir Oppor Infect Feb 10 14 2003 Hynes Conv Cent Boston Mass USA Conf Retrovir Oppor Infect 10th 2003 Boston Mass. 2003 Feb 10-14; 10: abstract no. 529. Univ of California at San Francisco BACKGROUND: Currently available approaches to measure adherence have notable limitations. Several studies have employed random antiretroviral drug levels as a candidate measure of adherence. We conducted a cross-sectional study to test the hypothesis that random measurements of antiretroviral drug levels correlate with level of adherence.METHODS: Antiretroviral drug levels were compared with objectively measured adherence in a prospective cohort of low-income HIV-positive adults (The REACH Cohort). Adherence was measured by unannounced pill counts. Plasma specimens were drawn within 1 month of the most recent adherence assessment.