Are NSAIDs contraindicated with concurrent use of Lovenox?
NSAIDs are not specifically contraindicated, but the Lovenox labeling includes a warning about the use of concomitant treatment with platelet inhibitors, such as aspirin. All NSAIDs inhibit platelet function and, as a result, may affect primary hemostasis. Aspirin is a particularly important NSAID in this regard since it irreversibly inhibits platelet function. The lifetime of a platelet is approximately 7 days, thus primary hemostasis will be affected for this period following treatment with ASA. Other NSAIDs have reversible platelet inhibiting effects but nevertheless may interfere with primary hemostasis. However, this inhibition is more transient, lasting 24 to 48 hours after cessation of use. In any event, the concomitant use of these agents with any antithrombotic agent, including Lovenox, may increase the possibility of bleeding, since both primary hemostasis and coagulation will be affected simultaneously. Lovenox should be used with care in patients receiving any platelet inhi
