Are neuroendocrine cells responsible for the development of benign prostatic hyperplasia?
OBJECTIVES: To examine the possible relationship between the distribution of neuroendocrine (NE) cells and the development of benign prostatic hyperplasia (BPH) in the human prostate, we performed an NE cells-distribution analysis and made morphological observations of acinous structures in different-aged prostates.METHODS: Forty-three human prostates obtained from surgical and autopsy cases aged from 2 months to 86 years were examined immunohistochemically using Chromogranin A and analyzed with special reference to the development of BPH.RESULTS: NE cells were distributed predominantly in the verumontanum and main prostatic ducts and were fewer in number in the terminal acini. As BPH development progressed, the NE cells were greatly diminished in number or completely lost from most adenoma nodules.CONCLUSIONS: The NE cells of the prostate may be distributed and transported from the periurethral region near the verumontanum to the terminal acini during the development of the acinar str
Related Questions
- How do patients with familial benign prostatic hyperplasia differ clinically from those with sporadic benign prostatic hyperplasia?
- Is there an association between water baths during labor and the development of chorioamnionitis or endometritis?
- Interstitial laser coagulation treatment of benign prostatic hyperplasia: is it to be recommended?
